The Dick Van Dyke Show had an episode about a handsome bachelor neighbor who moved in that everyone was trying to fix up but was uninterested. At the end, he told them he had beaten his former wife and didn't want to get involved with anyone. Kind of unusual for the tone of the show.
And there was the Mary Tyler Moore episode where she got -lightly - hooked on prescription drugs.
The most unusual I remember was the old 1960s anthology show, "The Name of the Game", which focused on 3 rotating leads - one was an industrialist played by Gene Barry. The plots were about high stakes business deals, intrigue, etc. - until one really unusual 2-hour episode, "Los Angeles A.D. 2017", where Barry's character, on the way back from an industrialists' conference on avoiding environmental restrictions, falls asleep at a rest stop, goes into suspended animation, and awakens in the year 2017, where a fascist state runs an underground Los Angeles in a polluted world, using sex as a way to divert the populace. Very odd SF episode in the middle of "Dallas" type plots. It was scripted by Philip Wylie (who wrote When Worlds Collide, The Disappearance, and other SF novels, as well as "Generation of Vipers", a very controversial book in the 1950s that is almost unknown now) and directed by a young Steven Spielberg.
"Flow with the Go."
- Rickson Gracie